Gomez-Rincon C, Langa E, Murillo P, Valero MS, Berzosa C, Lopez V.
BioMed Research International, 2014
Nematicidal activity of Melaleuca alternifolia essential oil, commonly known as tea tree oil (TTO), was assayed in vitro against L3 larvae of Anisakis simplex. The results showed a mortality of 100% for concentrations between 7 and 10 μ L/mL after 48 h of incubation, obtaining an LD50 value of 4.53 μ L/mL after 24 hours and 4.27 μ L/mL after 48 hours. Concentration-dependent inhibition of acetylcholinesterase was observed for tea tree essentialoil showing inhibition values of 100% at 100 μ L/mL. This fact suggests that TTO may act as an AChE inhibitor. Terpinen-4-ol was discarded as main larvicide compound as it did not show larvicidal or anticholinesterase activity. The data obtained suggest that the essential oil of Melaleuca alternifoliamay have a great therapeutic potential for the treatment of human anisakiasis.
Gomez-Rincon C, Langa E, Murillo P et al. Activity of Tea Tree (Melaleuca alternifolia) Essential Oil against L3 Larvae of Anisakis simplex. Biomed Res Int. doi: 10.1155/2014/549510