Alpha-bulnesene, a PAF inhibitor isolated from the essential oil of Pogostemon cablin

Tsai YC, Hsu HC, Yang WC, Tsai WJ, Chen CC, Watanabe T
Fitoterapia, 2007


ABSTRACT:

Steam distilled essential oil from the aerial parts of Pogostemon cablin was analyzed by gas chromatography–mass spectrometry (GC–MS). Forty one compounds were identified of which α-guaiene (20.62%) and α-bulnesene (16.18%) were major constituents. Furthermore, fractionation of the essential oil from P. cablin guided by inhibitory activity against PAF-induced platelet aggregation led to the isolation of the sesquiterpene, α-bulnesene.

CITATION:

Tsai YC, Hsu HC, Yang WC, Et Al. Alpha-bulnesene, a PAF inhibitor isolated from the essential oil of Pogostemon cablin. Fitoterapia. 2007 Jan;78(1):7-11.


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