Sun J, Wang X, Wang P, Li L, Liang J, Qu W
Journal of Ethnopharmacology, 2014
The aim of this study was to evaluate the antimicrobial and antioxidant activities of essential oil (EO) from Dictamnus angustifolius, correlated with their chemical composition and evaluate their cytotoxicity. As a result, 52 compounds representing the 97.2% of the total oil were identified by GC/MS. The major constituents of the oil were tetramethylenecyclobutane (42.07%) and fraxinellone (19.06%). The antimicrobial activity was evaluated against five microorganisms by the agar disc diffusion method and minimal inhibitory concentration (MIC) assay, which showed that the EO possess significant inhibition in Monilia albican ATCC 10231 and Staphylococcus aureus ATCC 6538. Antioxidant activity was measured by employing DPPH and FRAP assays, which suggested that the EO possess significant reducing power. Cytotoxic activity was evaluated in the mammalian cells lines A549, MCF7, B16 and LoVo using the MTT method to assess cell viability. The cytotoxic activity of the EO in MCF7 and B16 cells was significant stronger than in the other cell lines.
Sun J, Wang X, Wang P, et al. Antimicrobial, antioxidant and cytotoxic properties of essential oil from Dictamnus angustifolius. J Ethnopharmacol. 2014;doi:10.1016