Shanmuganathan B, Suryanarayanan V, Sathya S, Narenkumar M, Singh SK, Ruckmani K, Pandima Devi K European Journal of Medicinal Chemistry, 2017 ABSTRACT: Alzheimer’s disease (AD) is a life-threatening neurodegenerative disorder leading to dementia, with a progressive decline in memory and other thinking skills of elderly populace. Of the multiple etiological factors of AD, the accumulation… Read more »
Alpha-bisabolol
- Backbone: Sesquiterpene
- Functional Group: Alcohol
α-Bisabolol improves 5-aminolevulinic acid retention in buccal tissues: Potential application in the photodynamic therapy of oral cancer
Quintanilha NP, Dos Santos Miranda Costa I, Freiman de Souza Ramos M, Campos de Oliveira Miguel N, Riemma Pierre MB Journal of Photochemistry and Photobiology, 2017 CONTEXT: 5-Aminolevulinic acid (5-ALA) is a prodrug used in photodynamic therapy (PDT) of tumors, including cancer of the oral mucosa. 5-ALA poorly penetrates oral tissues due to its high… Read more »
Evidence for the involvement of the GABAergic, but not serotonergic transmission in the anxiolytic-like effect of bisabolol in the mouse elevated plus maze
Tabari MA, Tehrani MAB Naunyn-Schmiedeberg’s Archives of Pharmacology, 2017 ABSTRACT: Bisabolol (α-(-)-bisabolol) is a sesquiterpene which is a part of the essential oil of a variety of plants, but its common source is German chamomile. Several bioactivities including anti-inflammatory, anti-nociceptive, and anti-tumor effects were attributed to bisabolol. However, the neuropharmacological properties of bisabolol have not yet been reported…. Read more »
α-bisabolol-loaded lipid-core nanocapsules reduce lipopolysaccharide-induced pulmonary inflammation in mice
D’Almeida APL, Pacheco de Oliveira MT, de Souza ÉT, de Sá Coutinho D, Ciambarella BT, Gomes CR, Terroso T, Guterres SS, Pohlmann AR, Silva PM, Martins MA, Bernardi A International Journal of Nanomedicine, 2017 ABSTRACT: Acute respiratory distress syndrome (ARDS) is a severe clinical condition of respiratory failure due to an intense inflammatory response with different etiologies. Despite all efforts, therapy remains limited, and ARDS is… Read more »
β-Bisabolene, a Sesquiterpene from the Essential Oil Extract of Opoponax (Commiphora guidottii), Exhibits Cytotoxicity in Breast Cancer Cell Lines
Yeo SK, Ali AY, Hayward OA, Turnham D, Jackson T, Bowen ID, Clarkson R Phytotherapy research : PTR, 2016 ABSTRACT: The essential oils from Commiphora species have for centuries been recognized to possess medicinal properties. Here, we performed gas chromatography-mass spectrometry on the essential oil from opoponax (Commiphora guidotti) and identified bisabolene isomers as the… Read more »
Evaluation of the mutagenicity of sesquiterpenic compounds and their influence on the susceptibility towards antibiotics of two clinically relevant bacterial strains
Gonçalves O, Pereira R, Gonçalves F, Mendo S, Coimbra MA, Rocha SM
Mutation Research, 2011
α-(-)-bisabolol Reduces Pro-inflammatory Cytokine Production and Ameliorates Skin Inflammation.
Maurya AK, Singh M, Dubey V, Srivastava S, Luqman S, Bawankule DU
Current Pharmaceutical Biotechnology, 2014
Treatment of irritable bowel syndrome with herbal preparations: results of a double-blind, randomized, placebo-controlled, multi-centre trial
Madisch A, Holtmann G, Plein K, Hotz J
Alimentary pharmacology and & therapeutics, 2004
Proof of efficacy of Kamillosan(R) cream in atopic eczema
Patzelt-Wenczler R, Ponce-Pöschl E
European Journal of Medical Research, 2000
Effects of Essential Oils from Herbal Plants and Citrus Fruits on DNA Polymerase Inhibitory, Cancer Cell Growth Inhibitory, Antiallergic, and Antioxidant Activities
Mitoshi M, Kuriyama I, Nakayama H, Miyazato H, Sugimoto K, Kobayashi Y, Jippo T, Kanazawa K, Yoshida H, Mizushina Y
Journal of Agricultural and Food Chemistry, 2012