Copaiba Essential Oil

  • Botanical Name:  Copaifera spp.
  • Alternative Name: Copaiba Balsam Oil
  • Botanical Family: Fabaceae
  • Primary Constituent: Beta-Caryophyllene
  • Other Main Constituents: Bergamotene, Cadinene, Copaene, Humulene
  • Distillation Method: Steam distillation
  • Plant Part: Sap/Resin

Cadinene sesquiterpenes from Eupatorium adenophorum and their antifungal activity

Kundu A, Saha S, Walia S, Shakil NA, Kumar J, Annapurna K Journal of Environmental Science and Health, Part B, 2013 ABSTRACT: Bioactive constituents of Eupatorium adenophorum were investigated for antifungal activity. A structure-antifungal activity relationship of cadinene sesquiterpenes was predicted by evaluating individual derivatives. Cadinene derivatives were extracted from leaves of Eupatorium adenophorum using… Read more »

δ-Cadinene inhibits the growth of ovarian cancer cells via caspase-dependent apoptosis and cell cycle arrest

Hui LM, Zhao GD, Zhao JJ International Journal of Clinical and Experimental Pathology, 2015 ABSTRACT: Ovarian cancer is one of the most common causes of mortality among all cancers in females and is the primary cause of mortality from gynecological malignancies. The objective of the current research work was to evaluate a naturally occurring sesquiterpene-δ-Cadinene for… Read more »

Copaiba oil effect under different pathways in mice subjected to sepsis

Botelho NM, Silveira EL, Lopes LN, Santos FA, Teixeira RK, Silva TT Acta Cirurgica Brasileira, 2017 PURPOSE: To evaluate the effects of copaiba oil administered by different routes on survival of mices subjected to cecal ligation and puncture. METHODS: Thirty two mice were distributed into four study groups (N=8): Sham group: normal standard animals; CONTROL GROUP: submitted… Read more »

Potentiating effect of beta-caryophyllene on anticancer activity of alpha-humulene, isocaryophyllene and paclitaxel

Legault J, Pichette A Journal of Pharmacy and Pharmacology, 2017 ABSTRACT: Beta-caryophyllene is a sesquiterpene widely distributed in essential oils of various plants. Several biological activities are attributed to beta-caryophyllene, such as anti-inflammatory, antibiotic, antioxidant, anticarcinogenic and local anaesthetic activities. In this work, the potentiating effect of beta-caryophyllene on the anticancer activity of alpha-humulene, isocaryophyllene and paclitaxel… Read more »

Antimicrobial Activity of Copaiba (Copaifera officinalis) and Pracaxi (Pentaclethra macroloba) Oils against Staphylococcus Aureus: Importance in Compounding for Wound Care

Guimarães AL, Cunha EA, Matias FO, Garcia PG, Danopoulos P, Swikidisa R, Pinheiro VA, Nogueira RJ International Journal of Pharmaceutical Compounding, 2016 ABSTRACT: The Amazon rainforest is the largest reserve of natural products in the world. Its rich biodiversity of medicinal plants has been utilized by local populations for hundreds of years for the prevention… Read more »

Anti-Inflammatory and Antioxidant Actions of Copaiba Oil Are Related to Liver Cell Modifications in Arthritic Rats

Castro Ghizoni CV, Arssufi Ames AP, Lameira OA, Bersani Amado CA, Sá Nakanishi AB, Bracht L, Marçal Natali MR, Peralta RM, Bracht A, Comar JF Journal of Cellular Biochemistry, 2017 ABSTRACT: The present study investigated the action of copaiba oil (Copaifera reticulata) on the systemic inflammation, oxidative status, and liver cell metabolism of rats with adjuvant-induced arthritis…. Read more »

Effects of Copaiba Oil Topical Administration on Oral Wound Healing

Wagner VP, Webber LP, Ortiz L, Rados PV, Meurer L, Lameira OA, Lima RR, Martins MD Phytotherapy Research, 2017 ABSTRACT: The effects of topical copaiba oil extract and topical corticosteroid were assessed on oral wound healing in an in vivo model using 96 male Wistar rats. Traumatic ulcers were caused in the dorsum of the tongue using… Read more »

Anti-inflammatory Effect from a Hydrogel Containing Nanoemulsified Copaiba oil (Copaifera multijuga Hayne)

Lucca LG, de Matos SP, Kreutz T, Teixeira HF, Veiga VF Jr, de Araújo BV, Limberger RP, Koester LS AAPS PharmSciTech, 2017 ABSTRACT: Copaiba oil is used as a popular medicine in the Amazonian forest region, especially due to its anti-inflammatory properties. In this paper, we describe the formulation of hydrogel containing copaiba oil nanoemulsions (with positive and… Read more »

Copaiba oil: chemical composition and influence on in vitro cutaneous permeability of Celecoxib.

Quiñones OG, Abranches RP, Nakamura MJ, de Souza Ramos MF, Pierre MBR Current Drug Delivery, 2017 BACKGROUND: Use of topical or transdermal administration of Celecoxib (Cxb) is an interesting strategy in cutaneous treatments since it reduces or avoids side effects of the oral route. However, Cxb´s high lipophilicity and the stratum corneum (SC) barrier impair… Read more »

Antimicrobial activity of copaiba oil: A review and a call for further research

Tobouti PL, de Andrade Martins TC, Pereira TJ, Mussi MCM Biomedicine & Pharmacotherapy, 2017 ABSTRACT: Copaiba oil has been used for more than 390 years, however, considering the time of empirical use, there are a scarce number of publications on its activities. This essential oil is a phytomedicine proven to be efficient against some microorganisms. However, different from other… Read more »