• Backbone: Sesquiterpene
  • Functional Group: None

Clove extract functions as a natural fatty acid synthesis inhibitor and prevents obesity in a mouse model

Ding Y, Gu Z, Wang Y, Wang S, Chen H, Zhang H, Chen W, Chen YQ Food & Function, 2017 ABSTRACT: Numerous medicinal plants have been reported to prevent various chronic diseases. In this study, we screened a new FASN inhibitor-alcohol extract of clove (AEC) using a fast microplate method developed in our laboratory. The major components of AEC were: eugenol (42.27%), acetyl eugenol (29.12%), caryophyllene (15.40%), and… Read more »

Antiallodynic effect of β-caryophyllene on paclitaxel-induced peripheral neuropathy in mice

Segat GC, Manjavachi MN, Matias DO, Passos GF, Freitas CS, Costa R, Calixto JB Neuropharmacology, 2017 ABSTRACT: Painful peripheral neuropathy is a common side effect of paclitaxel (PTX). The use of analgesics is an important component for management of PTX-induced peripheral neuropathy (PINP). However, currently employed analgesics have several side effects and are poorly effective. β-caryophyllene (BCP), a dietary selective CB2 agonist, has… Read more »

Prebiotic Potential and Chemical Composition of Seven Culinary Spice Extracts

Lu QY, Summanen PH, Lee RP, Huang J, Henning SM, Heber D, Finegold SM, Li Z Journal of Food Science, 2017 ABSTRACT: The objective of this study was to investigate prebiotic potential, chemical composition, and antioxidant capacity of spice extracts. Seven culinary spices including black pepper, cayenne pepper, cinnamon, ginger, Mediterranean oregano, rosemary, and turmeric were extracted with boiling water. Major chemical… Read more »

Neuroprotective Effects of β-Caryophyllene against Dopaminergic Neuron Injury in a Murine Model of Parkinson’s Disease Induced by MPTP

Viveros-Paredes JM, González-Castañeda RE, Gertsch J, Chaparro-Huerta V, López-Roa RI, Vázquez-Valls E, Beas-Zarate C, Camins-Espuny A, Flores-Soto ME Pharmaceuticals (Basel, Switzerland), 2017 ABSTRACT: Parkinson’s disease (PD) is one of the most common neurodegenerative disorders and is characterized by the loss of dopaminergic neurons in the substantia nigra (SN). Although the causes of PD are not understood, evidence suggests that its pathogenesis is associated… Read more »

Essential Oils of Oregano: Biological Activity beyond Their Antimicrobial Properties

Leyva-López N, Gutiérrez-Grijalva EP, Vazquez-Olivo G, Heredia JB Molecules, 2017 ABSTRACT: Essential oils of oregano are widely recognized for their antimicrobial activity, as well as their antiviral and antifungal properties. Nevertheless, recent investigations have demonstrated that these compounds are also potent antioxidant, anti-inflammatory, antidiabetic and cancer suppressor agents. These properties of oregano essential oils are of potential interest to the food,… Read more »

Phytochemical and pharmacological properties of essential oils from Cedrus species

Saab AM, Gambari R, Sacchetti G, Guerrini A, Lampronti I, Tacchini M, El Samrani A, Medawar S, Makhlouf H, Tannoury M, Abboud J, Diab-Assaf M, Kijjoa A, Tundis R, Aoun J, Efferth T Natural Product Research, 2017 ABSTRACT: Natural products frequently exert pharmacological activities. The present review gives an overview of the ethnobotany, phytochemistry and pharmacology of the Cedrus genus, e.g. cytotoxic, spasmolytic immunomodulatory, antiallergic, anti-inflammatory and analgesic activities. Cancer… Read more »

β-Caryophyllene ameliorates the Alzheimer-like phenotype in APP/PS1 Mice through CB2 receptor activation and the PPARγ pathway

Cheng Y, Dong Z, Liu S Pharmacology, 2014 ABSTRACT: BACKGROUND/AIMS: The activation of cannabinoid receptor 2 (CB2) has the beneficial effect of reducing neuroinflammatory response in the treatment of Alzheimer’s disease (AD) and is suggested to trigger the peroxisome proliferator-activated receptor-γ (PPARγ) pathway; agonists of both receptors improve AD. Recently, the plant metabolite β-caryophyllene was… Read more »

The Effects of Selected Sesquiterpenes from Myrica rubra Essential Oil on the Efficacy of Doxorubicin in Sensitive and Resistant Cancer Cell Lines

Ambrož M, Matoušková P, Skarka A, Zajdlová M, Žáková K, Skálová L Molecules, 2017 ABSTRACT: β-caryophyllene oxide (CAO), α-humulene (HUM), trans-nerolidol (NER) and valencene (VAL) are constituents of the essential oil of Myrica rubra (MEO), which has significant antiproliferative effect in various cancer cell lines. In the present study, we compared the antiproliferative effect of… Read more »

Anticonvulsant activity of β-caryophyllene against pentylenetetrazol-induced seizures

de Oliveira CC, de Oliveira CV, Grigoletto J, Ribeiro LR, Funck VR, Grauncke AC, de Souza TL, Souto NS, Furian AF, Menezes IR, Oliveira MS Epilepsy & behavior : E&B, 2016 ABSTRACT: Increasing evidence suggests that plant-derived extracts and their isolated components are useful for treatment of seizures and, hence, constitute a valuable source of… Read more »