Terpinen-4-ol

  • Backbone: Monoterpene
  • Functional Group: Alcohol

Antimicrobial activity of essential oils against multidrug-resistant clinical isolates of the Burkholderia cepacia complex

Vasireddy L, Bingle LEH, Davies MS PLoS ONE, 2018 ABSTRACT: Members of the Burkholderia cepacia complex (Bcc) are an important cause of opportunistic or nosocomial infections that may be hard to treat due to a high incidence of multidrug resistance. We characterised a collection of 51 clinical isolates from this complex, assigning them to 18… Read more »

The anticonvulsant and anti-plasmid conjugation potential of Thymus vulgaris chemistry: An in vivo murine and in vitro study

Skalicka-Woźniak K, Walasek M, Aljarba TM, Stapleton P, Gibbons S, Xiao J, Łuszczki JJ Food and Chemical Toxicology, 2018 ABSTRACT: The high-performance counter-current chromatography was used for the efficient purification of single constituents from Thymus vulgaris essential oil. Mixtures of n-heptane, ethyl acetate, methanol, and water (5:2:5:2 and 4:1:4:1 v/v), allowed purification of eugenol, 1-octen-3-… Read more »

Melaleuca alternifolia essential oil prevents bioenergetics dysfunction in spleen of silver catfish naturally infected with Ichthyophthirius multifiliis

Baldissera MD, Souza CF, Baldisserotto B Microbial Pathogenesis, 2018 ABSTRACT: Some evidence has demonstrated that Ichthyophthirius multifiliis, etiologic agent of “white spot disease”, causes severe bioenergetics dysfunction in the spleen of naturally infected silver catfish (Rhamdia quelen), which contributes directly to disease pathogenesis. Recently, several studies have demonstrated the efficacy of Melaleuca alternifolia essential oil,… Read more »

Structure-activity modelling of essential oils, their components, and key molecular parameters and descriptors

Owen L, Laird K, Wilson PB Molecular and Cellular Probes, 2017 ABSTRACT: Many essential oil components are known to possess broad spectrum antimicrobial activity, including against antibiotic resistant bacteria. These compounds may be a useful source of new and novel antimicrobials. However, there is limited research on the structure-activity relationship (SAR) of essential oil compounds,… Read more »

The antifungal activity of essential oil from Melaleuca leucadendra (L.) L. grown in China and its synergistic effects with conventional antibiotics against Candida

Zhang J, Wu H, Jiang D, Yang Y, Tang W, Xu K Natural Product Research, 2018 ABSTRACT: To identify the natural antifungal agents, the antifungal activities of Melaleuca leucadendra (L.) L. essential oil (ML-EO) from Fujian Province of China were assayed. Treatment of ML-EO in combination with the front-line using antibiotics against Candida led to… Read more »

Evaluation of anti-enzyme properties of Origanum vulgare essential oil against oral Candida albicans

Pradebon Brondani L, Alves da Silva Neto T, Antonio Freitag R, Guerra Lund R Journal de Mycologie Medicale, 2018 ABSTRACT: This study aimed to evaluate the anti-enzymatic activity of Origanum vulgare (oregano) essential oil against 15 strains of Candida albicans. Candida albicans samples were isolated from the oral mucosa of patients with denture stomatitis treated… Read more »

Lactoferrin, chitosan and Melaleuca alternifolia-natural products that show promise in candidiasis treatment

Felipe LO, Júnior WFDS, Araújo KC, Fabrino DL Brazilian Journal of Microbiology, 2017 ABSTRACT: The evolution of microorganisms resistant to many medicines has become a major challenge for the scientific community around the world. Motivated by the gravity of such a situation, the World Health Organization released a report in 2014 with the aim of… Read more »

Melaleuca alternifolia Induces Heme Oxygenase-1 Expression in Murine RAW264.7 Cells through Activation of the Nrf2-ARE Pathway

Lee SY, Chen PY, Lin JC, Kirkby NS, Ou CH, Chang TC American Journal of Chinese Medicine, 2017 ABSTRACT: Melaleuca alternifolia concentrate (MAC) is the refined essential oil of the Australian native plant Melaleuca alternifolia. MAC has been reported to suppress the production of pro-inflammatory cytokines in both murine RAW264.7 macrophages and human monocytes stimulated with lipopolysaccharide… Read more »

Evaluation of the Constituents of Vetiver Oil Against Anopheles minimus (Diptera: Culicidae), a Malaria Vector in Thailand

Tisgratog R, Sukkanon C, Grieco JP, Sanguanpong U, Chauhan KR, Coats JR, Chareonviriyaphap T Journal of Medical Entomology, 2017 ABSTRACT: The development of resistance by mosquitoes to current synthetic compounds has resulted in reduced effectiveness of prevention and control methods worldwide. An alternative nonchemical based control tools are needed to be evaluated particularly plant-derived essential oils…. Read more »

Four terpene synthases contribute to the generation of chemotypes in tea tree (Melaleuca alternifolia)

Padovan A, Keszei A, Hassan Y, Krause ST, Köllner TG, Degenhardt J, Gershenzon J, Külheim C, Foley WJ BMC Plant Biology, 2017 BACKGROUND: Terpene rich leaves are a characteristic of Myrtaceae. There is significant qualitative variation in the terpene profile of plants within a single species, which is observable as “chemotypes”. Understanding the molecular basis… Read more »