Akutsu H, Kikusui T, Takeuchi Y, Mori Y
The Journal of Veterinary Medical Science, 2003
Stress-induced hyperthermia is observed in animals exposed to stressful conditions. In our previous study, plant-derived fragrances such as green odor and alpha-pinene were shown to suppress this stress response in rats. In the present study, we examined the concentration-dependence of the alpha-pinene effects on stress-induced hyperthermia. Male rats carrying telemetry transmitters were transferred individually to a new cage containing bedding that had been sprayed with 0.3, 0.03, and 0.003% concentrations of alpha-pinene or control solvent. Following transfer to the novel environment, the body temperature increased significantly, and this response was clearly suppressed when the cage was scattered with 0.03% alpha-pinene only. These results suggest that the effect of alpha-pinene on stress-induced hyperthermia can be observed only at a certain concentration.
Akutsu H, Kikusui T, Takeuchi Y, et al. Effects of alpha-pinene odor in different concentrations on stress-induced hyperthermia in rats. J Vet Med Sci. 2003;65(9):1023-1025.