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Nilesh M, Dinesh S, Dhirendra S
International Journal of Pharmaceutical Sciences, 2009
ABSTRACT:
The leaves of Jasminum grandiflorum L. (Family: Oleaceae) is used in folk medicine for treating ulcerative stomatitis, skin diseases, ulcers, wounds, etc. Anti ulcer activity of hydro alcoholic extract of leaves of Jasminum grandiflorum L. was evaluated employing aspirin + pylorus ligation (APL) induced acute gastric ulcer models in albino rats. The effect of ethanolic extract of leaves of Jasminum grandiflorum L. (100 and 200 mg/kg, b.w., orally) on the volume of gastric juice, gastric pH, total acid, free acid and ulcer induces in the pyloric ñlegated rats was studied for the assessment of antiulcer activity. There was a significant (P < 0.01) dose-dependent decrease in the ulcerative lesion index produced by aspirin + pylorus ligation (APL) induced acute gastric ulcer models in albino rats as compared to the standard drug Omeprazole (30 mg/kg, b.w. orally). The reduction in gastric fluid volume, free acid, total acid and an increase in the pH of the gastric fluid in APL rats proved the antisecretory and potential antiulcer activity of leaves of Jasminum grandiflorum L.
CITATION:
Nilesh M, Dinesh S, Dhirendra S. Evaluation of anti-ulcer potential of leaves of Jasminum grandiflorum L. Int J Pharm Sci. 2009;1(2):247-249.
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