Zeng H, Chen X, Liang J
Journal of Medical Microbiology, 2014
The fennel seeds essential oil (FSEO) is a kind of plant-derived natural therapeutics against dermatophytes. In this study, the antifungal effects of the FESO were investigated from varied aspects, such as the MIC and MFC, mycelia growth, spores germination and biomass. The results indicated that the FSEO had potent antifungal activities on T. rubrum ATCC4005, T. tonsurans 10-0400, M. gypseum 44693-1 and T. mentagrophytes 10-0060, which is better than the commonly used antifungal agents fluconazole (FCZ) and Amphotericin B (AmB). Flow cytometry and Transmission electron microscopy (TEM) experiments suggested that the antifungal mechanism of the FSEO was to damage the plasma membrane and intracellular organelles. Further study revealed that it could also inhibit the mitochondrial enzymes activities, such as succinate dehydrogenase (SDH), malate dehydrogenase (MDH) and ATPase. With better antifungal activity than the commonly used antifungal agents and less possibility to induce drug resistance, the FSEO could be used as a potential antidermatophytic agent.
Zeng H, Chen X, Liang J. In vitro antifungal activity and mechanism of essential oil from fennel ( Foeniculum vulgare L.) on dermatophyte species. J Med Microbiol. 2014;pii:jmm.0.077768-0.