(-)-Linalool influence on the cerebral blood flow in healthy male volunteers revealed by three-dimensional pseudo-continuous arterial spin labeling

Ota M, Sato N, Sone D, Ogura J, Kunugi H
Indian Journal of Psychiatry, 2017


BACKGROUND:

Although aromatherapy is widely used, the pharmacology of the essential oils remains undiscovered.

AIM:

The present study assessed the effect of (-)-linalool, the main contained material of lavender, on the brain function.

MATERIALS AND METHODS:

Healthy male volunteers calculated the regional cerebral blood flow (CBF) before and after inhalation of (-)-linalool, and CBF changes were evaluated.

RESULTS:

There were significant CBF reductions in the right superior temporal gyrus to insula, anterior cingulate cortex after inhalation.

CONCLUSIONS:

The previous study detected the regulatory influence of (-)-linalool on the glutamatergic transmission. The effect of (-)-linalool on the ACC and insula would cause the sedative and anxiolytic activity.

CITATION:

Ota M, Sato N, Sone D et al. (-)-Linalool influence on the cerebral blood flow in healthy male volunteers revealed by three-dimensional pseudo-continuous arterial spin labeling. Indian J Psychiatry. 2017 Apr-Jun;59(2):225-227. doi: 10.4103/psychiatry.IndianJPsychiatry_323_16.


 
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