Abe S, Maruyama N, Hayama K, Inouye S, Oshima H, Yamaguchi H
Mediators of Inflammation, 2004
ABSTRACT:
BACKGROUND:
In aromatherapy, essential oils are used as anti-inflammatory remedies, but experimental studies on their action mechanisms are very limited.
AIMS OF THE STUDY:
To assess their anti-inflammatory activities, the effects of essential oils on neutrophil recruitment in mice were examined in vivo.
METHOD:
The effect of essential oils on leukocyte and neutrophil recruitment induced 6 h after intraperitoneal injection of casein in mice was examined.
RESULTS:
Leukocyte recruitment into the peritoneal cavity in mice was suppressed by intraperitoneal injections of geranium, lemongrass and spearmint oils at the dose of 5 microl/mouse, but was not by tea tree oil. This recruitment was inhibited dose-dependently by geranium oil. The suppression of leukocyte recruitment resulted from inhibition of neutrophil accumulation.
CONCLUSION:
Some essential oils used as anti-inflammatory remedies suppress neutrophil recruitment into the peritoneal cavity in mice.
CITATION:
Abe S, Maruyama N, Hayama K, Et Al. Suppression of neutrophil recruitment in mice by geranium essential oil. Mediators Inflamm. 2004;13(1):21-24.
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