Safranal protects against beta-amyloid peptide-induced cell toxicity in PC12 cells via MAPK and PI3 K pathways

Rafieipour F, Hadipour E, Emami SA, Asili J, Tayarani-najaran Z Metabolic Brain Disease, 2018 ABSTRACT: Alzheimer’s disease is a type of cerebrovascular problem with progressive mental disabilities for the patient. This study aimed to investigate the protective effect of safranal on toxicity and oxidative damage induced by beta-amyloid (Aβ) and hydrogen peroxide (H2O2) in PC12… Read more »

Neuropharmacological Properties of the Essential Oil of Bergamot for the Clinical Management of Pain-Related BPSDs

Scuteri D, Rombola L, Tridico L, Mizoguchi H, Watanabe C, Sakurada T, Sakurada S, Corasaniti MT, Bagetta G, Morrone LA Current Medicinal Chemistry, 2018 ABSTRACT: BACKGROUND: Alzheimer’s Disease (AD) accounts for approximately 50% of all cases of dementia and, in spite of the great effort for the development of disease-modifying drugs, a definitive treatment of… Read more »

β-Caryophyllene ameliorates the Alzheimer-like phenotype in APP/PS1 Mice through CB2 receptor activation and the PPARγ pathway

Cheng Y, Dong Z, Liu S Pharmacology, 2014 ABSTRACT: BACKGROUND/AIMS: The activation of cannabinoid receptor 2 (CB2) has the beneficial effect of reducing neuroinflammatory response in the treatment of Alzheimer’s disease (AD) and is suggested to trigger the peroxisome proliferator-activated receptor-γ (PPARγ) pathway; agonists of both receptors improve AD. Recently, the plant metabolite β-caryophyllene was… Read more »

Diterpenes: Advances in Neurobiological Drug Research

Islam MT, da Silva CB, de Alencar MV, Paz MF, Almeida FR, Melo-Cavalcante AA Phytotherapy research, 2016 ABSTRACT: A significant number of studies have been performed with diterpene effect on the brain. Our study aims to make a systematic revision on them. The initial purpose of this review was to screen diterpenes with neurological activity,… Read more »

Essential oils from Apiaceae as valuable resources in neurological disorders: Foeniculi vulgare aetheroleum

Cioancaa O, Hancianua M, Mirceab C, Trifana A, Hritcuc L Industrial Crops and Products, 2016 ABSTRACT: Used as a spice and to improve the palatability of different meat and vegetable dishes, common fennel, Foeniculum vulgare Mill. (Apiaceae), was a traditional remedy for the relief of spasms and colic due to gas accumulation, to stimulate gastrointestinal… Read more »

Linalool reverses neuropathological and behavioral impairments in old triple transgenic Alzheimer’s mice

Sabogal-Guáqueta AM, Osorio E, Cardona-Gómez GP Neuropharmacology, 2016 ABSTRACT: Alzheimer’s disease (AD) is an age-related progressive neurodegenerative disorder. Several types of treatments have been tested to block or delay the onset of the disease, but none have been completely successful. Diet, lifestyle and natural products are currently the main scientific focuses. Here, we evaluate the… Read more »