Eskandari-roozbahani N, Shomali T, Taherianfard M Basic and Clinical Neuroscience, 2019 ABSTRACT: INTRODUCTION: Finding herbs with promising effects to prevent or postpone Alzheimer Disease (AD) is highly demanded. The present study aimed at clarifying plausible effects and related mechanism(s) of Zataria Multiflora Essential Oil (ZMEO) against memory impairment in a rat model of the AD…. Read more »
Tetraclinis articulata essential oil mitigates cognitive deficits and brain oxidative stress in an Alzheimer’s disease amyloidosis model
Sadiki FZ, Idrissi ME, Cioanca O, Trifan A, Hancianu M, Hritcu L, Postu PA Phytomedicine, 2018 ABSTRACT: BACKGROUND: Tetraclinis articulata is used in traditional medicine and has been reported to possess antibacterial, antifungal, cytotoxic, anti-inflammatory and antioxidant properties. PURPOSE: This study investigated the effects of T. articulata essential oil on memory and brain oxidative stress… Read more »
Safranal protects against beta-amyloid peptide-induced cell toxicity in PC12 cells via MAPK and PI3 K pathways
Rafieipour F, Hadipour E, Emami SA, Asili J, Tayarani-najaran Z Metabolic Brain Disease, 2018 ABSTRACT: Alzheimer’s disease is a type of cerebrovascular problem with progressive mental disabilities for the patient. This study aimed to investigate the protective effect of safranal on toxicity and oxidative damage induced by beta-amyloid (Aβ) and hydrogen peroxide (H2O2) in PC12… Read more »
Neuropharmacological Properties of the Essential Oil of Bergamot for the Clinical Management of Pain-Related BPSDs
Scuteri D, Rombola L, Tridico L, Mizoguchi H, Watanabe C, Sakurada T, Sakurada S, Corasaniti MT, Bagetta G, Morrone LA Current Medicinal Chemistry, 2018 ABSTRACT: BACKGROUND: Alzheimer’s Disease (AD) accounts for approximately 50% of all cases of dementia and, in spite of the great effort for the development of disease-modifying drugs, a definitive treatment of… Read more »
Trans-caryophyllene inhibits amyloid β (Aβ) oligomer-induced neuroinflammation in BV-2 microglial cells
Hu Y, Zeng Z, Wang B, Guo S International Immunopharmacology, 2017 ABSTRACT: Amyloid β (Aβ) is the major component of senile plaques (SP) in the brains of Alzheimer’s disease (AD) patients, and serves as an inflammatory stimulus for microglia. Trans-caryophyllene (TC), a major component in the essential oils derived from various species of medicinal plants, has displayed… Read more »
β-Caryophyllene ameliorates the Alzheimer-like phenotype in APP/PS1 Mice through CB2 receptor activation and the PPARγ pathway
Cheng Y, Dong Z, Liu S Pharmacology, 2014 ABSTRACT: BACKGROUND/AIMS: The activation of cannabinoid receptor 2 (CB2) has the beneficial effect of reducing neuroinflammatory response in the treatment of Alzheimer’s disease (AD) and is suggested to trigger the peroxisome proliferator-activated receptor-γ (PPARγ) pathway; agonists of both receptors improve AD. Recently, the plant metabolite β-caryophyllene was… Read more »
Neuroprotective and Anti-Aging Potentials of Essential Oils from Aromatic and Medicinal Plants
Ayaz M, Sadiq A, Junaid M, Ullah F, Subhan F, Ahmed J Frontiers in Aging Neuroscience, 2017 ABSTRACT: The use of essential oils (EOs) and their components is known since long in traditional medicine and aromatherapy for the management of various diseases, and is further increased in the recent times. The neuroprotective and anti-aging potentials… Read more »
Diterpenes: Advances in Neurobiological Drug Research
Islam MT, da Silva CB, de Alencar MV, Paz MF, Almeida FR, Melo-Cavalcante AA Phytotherapy research, 2016 ABSTRACT: A significant number of studies have been performed with diterpene effect on the brain. Our study aims to make a systematic revision on them. The initial purpose of this review was to screen diterpenes with neurological activity,… Read more »
Essential oils from Apiaceae as valuable resources in neurological disorders: Foeniculi vulgare aetheroleum
Cioancaa O, Hancianua M, Mirceab C, Trifana A, Hritcuc L Industrial Crops and Products, 2016 ABSTRACT: Used as a spice and to improve the palatability of different meat and vegetable dishes, common fennel, Foeniculum vulgare Mill. (Apiaceae), was a traditional remedy for the relief of spasms and colic due to gas accumulation, to stimulate gastrointestinal… Read more »
Linalool reverses neuropathological and behavioral impairments in old triple transgenic Alzheimer’s mice
Sabogal-Guáqueta AM, Osorio E, Cardona-Gómez GP Neuropharmacology, 2016 ABSTRACT: Alzheimer’s disease (AD) is an age-related progressive neurodegenerative disorder. Several types of treatments have been tested to block or delay the onset of the disease, but none have been completely successful. Diet, lifestyle and natural products are currently the main scientific focuses. Here, we evaluate the… Read more »