Russo A, Cardile V, Graziano ACE, Avola R, Bruno M, Rigano D International Journal of Molecular Sciences, 2018 ABSTRACT: Prostate cancer is one of the most common forms of cancer in men, and research to find more effective and less toxic drugs has become necessary. In the frame of our ongoing program on traditionally used… Read more »
Modulation of diverse oncogenic transcription factors by thymoquinone, an essential oil compound isolated from the seeds of Nigella sativa Linn
Shanmugam MK, Arfuso F, Kumar AP, Wang L, Goh BC, Ahn KS, Bishayee A, Sethi G Pharmacology Research, 2017 ABSTRACT: Thymoquinone (TQ), isolated almost fifty years ago, is the main bioactive constituent of black seed essential oil extracted from the seed of Nigella sativa. TQ has been shown to have promising effects against a variety of inflammatory… Read more »
Apoptotic Effect of Nigella sativa on Human Lymphoma U937 Cells
Arslan BA, Isik FB, Gur H, Ozen F, Catal T Pharmacognosy Magazine, 2017 OBJECTIVE: Nigella sativa is from botanical Ranunculaceae family and commonly known as black seed. Apoptotic effect of N. sativa and its apoptotic signaling pathways on U937 lymphoma cells are unknown. MATERIALS AND METHODS: In this study, we investigated selective cytotoxic and apoptotic effects of N. sativa extract… Read more »
Frankincense, pine needle and geranium essential oils suppress tumor progression through the regulation of the AMPK/mTOR pathway in breast cancer
Ren P, Ren X, Cheng L, Xu L Oncology reports, 2017 ABSTRACT: BC (BC), as the most common malignancy in women worldwide, is associated with high morbidity and mortality. However, chemoresistance and toxicity are the main causes that limit the success of treatment in aggressive BC cases. Thus, there is a vital need to identify and… Read more »
δ-Cadinene inhibits the growth of ovarian cancer cells via caspase-dependent apoptosis and cell cycle arrest
Hui LM, Zhao GD, Zhao JJ International Journal of Clinical and Experimental Pathology, 2015 ABSTRACT: Ovarian cancer is one of the most common causes of mortality among all cancers in females and is the primary cause of mortality from gynecological malignancies. The objective of the current research work was to evaluate a naturally occurring sesquiterpene-δ-Cadinene for… Read more »
Chemical Composition, Cytotoxic, Apoptotic and Antioxidant Activities of Main Commercial Essential Oils in Palestine: A Comparative Study
A Al-Tamimi M, Rastall B, M Abu-Reidah I Medicines (Basel), 2016 ABSTRACT: Background: Essential oils (EOs) are complex mixtures of several components gifted with a wide array of biological activities. The present research was designed to evaluate whether commercial essential oils could be effective by examining their in vitro antioxidant, cytotoxic, and apoptotic properties of nine commercially available EOs… Read more »
Can Ocimum basilicum relieve chronic unpredictable mild stress-induced depression in mice?
Ayuob NN, Firgany AEL, El-Mansy AA, Ali S Experimental and Molecular Pathology BACKGROUND: Depression is one of the important world-wide health problems. OBJECTIVES: This study aimed to assess the ameliorative effect of Ocimum basilicum (OB) essential oil on the behavioral, biochemical and histopathological changes resulted from exposure to chronic unpredictable mild stress (CUMS). It also aimed to… Read more »
Terpinen-4-ol inhibits colorectal cancer growth via reactive oxygen species
Nakayama K, Murata S, Ito H, Iwasaki K, Villareal MO, Zheng YW, Matsui H, Isoda H, Ohkohchi N Oncology Letters, 2017 ABSTRACT: Terpinen-4-ol (TP4O) is the main component of the essential oil extracted from Melaleuca alternifolia, known as the tea tree, of the botanical family Myrtaceae. The anticancer effects of TP4O have been reported in several cancer cell… Read more »
Anethole Inhibits The Proliferation Of Human Prostate Cancer Cells Via Induction Of Cell Cycle Arrest And Apoptosis
Elkady AI Anti-Cancer Agents in Medicinal Chemistry, 2017 ABSTRACT: BACKGROUND: Prostate cancer-associated mortality is increasing at an alarming rate, which highlights the inevitability for unearthing novel agent for the management of this disease. Anethole, a major constituent of Foeniculum vulgare (fennel) essential oil, is widely used in folk medicine; it possesses anti-oxidant, anti-inflammatory, anti-proliferative and tumoricidal potentialities…. Read more »
The Effect of Thymoquinone on Apoptosis of SK-OV-3 Ovarian Cancer Cell by Regulation of Bcl-2 and Bax
Liu X, Dong J, Cai W, Pan Y, Li R, Li B International Journal of Gynecological Cancer, 2017 ABSTRACT: OBJECTIVE: We aim to determine how cisplatin, thymoquinone (TQ), and combination regimen can affect apoptosis of cultured SK-OV-3 cells. We also want to explore the mechanism of these influences on the cells’ apoptosis by Bcl-2 and Bax gene. METHOD/MATERIALS: Cell Counting Kit-8 assay… Read more »