Antiallodynic effect of β-caryophyllene on paclitaxel-induced peripheral neuropathy in mice

Segat GC, Manjavachi MN, Matias DO, Passos GF, Freitas CS, Costa R, Calixto JB Neuropharmacology, 2017 ABSTRACT: Painful peripheral neuropathy is a common side effect of paclitaxel (PTX). The use of analgesics is an important component for management of PTX-induced peripheral neuropathy (PINP). However, currently employed analgesics have several side effects and are poorly effective. β-caryophyllene (BCP), a dietary selective CB2 agonist, has… Read more »

Ligands for cannabinoid receptors, promising anticancer agents

Nikan M, Nabavi SM, Manayi A Life Sciences, 2016 ABSTRACT: Cannabinoid compounds are unique to cannabis and provide some interesting biological properties. These compounds along with endocannabinoids, a group of neuromodulator compounds in the body especially in brain, express their effects by activation of G-protein-coupled cannabinoid receptors, CB1 and CB2. There are several physiological properties… Read more »