Interaction of human telomeric G-quadruplex DNA with thymoquinone: a possible mechanism for thymoquinone anticancer effect

Salem AA, El Haty IA, Abdou IM, Mu Y Biochimica et Biophysica Acta, 2015 ABSTRACT: BACKGROUND: Thymoquinone (TQ) has been documented to possess chemo-preventive and chemotherapeutic antitumor effects. Studies reported that TQ inhibits the growth of cancer cells in animal models, culture and xenografted tumors. Molecular mechanisms underlying these anticancer effects were attributed to inductions of cell cycle arrest,… Read more »

The eucalyptus oil ingredient 1,8-cineol induces oxidative DNA damage

Dörsam B, Wu CF, Efferth T, Kaina B, Fahrer J Archives of toxicology, 2015 ABSTRACT: The natural compound 1,8-cineol, also known as eucalyptol, is a major constituent of eucalyptus oil. This epoxy-monoterpene is used as flavor and fragrance in consumer goods as well as medical therapies. Due to its anti-inflammatory properties, 1,8-cineol is also applied… Read more »