Guimarães AC, Meireles LM, Lemos MF, Guimarães MCC, Endringer DC, Fronza M, Scherer R Molecules, 2019 ABSTRACT: Background: The antimicrobial activity of essential oils has been reported in hundreds of studies, however, the great majority of these studies attribute the activity to the most prevalent compounds without analyzing them independently. Therefore, the aim was to… Read more »
Essential Oils for the Treatment of Herpes Simplex Virus Infections
Schnitzler P Chemotherapy, 2019 ABSTRACT: Infections with herpes simplex virus type (HSV)-1 and HSV-2 are distributed worldwide. Although standard therapies with acyclovir and other synthetic drugs are available, the safety and efficacy of these drugs are limited due to the development of drug resistance and adverse side effects. The literature on essential oils and isolated… Read more »
Volatile Terpenes and Brain Function: Investigation of the Cognitive and Mood Effects of Mentha × Piperita L. Essential Oil with In Vitro Properties Relevant to Central Nervous System Function
Kennedy D, Okello E, Chazot P, Howes MJ, Ohiomokhare S, Jackson P, Haskell-Ramsay C, Khan J, Forster J, Wightman E Nutrients, 2018 ABSTRACT: Extracts of several members of the monoterpene-rich Lamiaceae sub-family Nepetoideae, including those from the Salvia (sage), Melissa (Lemon balm) and Rosmarinus (rosemary) genera, evince cognitive and mood effects in humans that are… Read more »
The anticonvulsant and anti-plasmid conjugation potential of Thymus vulgaris chemistry: An in vivo murine and in vitro study
Skalicka-Woźniak K, Walasek M, Aljarba TM, Stapleton P, Gibbons S, Xiao J, Łuszczki JJ Food and Chemical Toxicology, 2018 ABSTRACT: The high-performance counter-current chromatography was used for the efficient purification of single constituents from Thymus vulgaris essential oil. Mixtures of n-heptane, ethyl acetate, methanol, and water (5:2:5:2 and 4:1:4:1 v/v), allowed purification of eugenol, 1-octen-3-… Read more »
Terpenes, Phenylpropanoids, Sulfur and Other Essential Oil Constituents as Inhibitors of Cholinesterases
Politeo O, Burcul F, Blazevic I, Radan M Current Medicinal Chemistry, 2018 ABSTRACT: Essential oils constituents are a diverse family of low molecular weight organic compounds with comprehensive biological activity. According to their chemical structure these active compounds can be divided into four major groups: terpenes, terpenoids, phenylpropenes, and “others”. In addition, they may contain… Read more »
Selected terpenes from leaves of Ocimum basilicum L. induce hemoglobin accumulation in human K562 cells
Giordana F, Nicola M, Valentina C, Torricelli P, Beninati S, Tagliati F, Mischiati C Fitoterapia, 2018 ABSTRACT: Re-expression of fetal hemoglobin (HbF) was proposed as a possible therapeutic strategy for β-haemoglobinopathies. Although several inducers of HbF were tested in clinical trials, only hydroxyurea (HU) received FDA approval. Despite it produced adequate HbF levels only in… Read more »
Analgesic-Like Activity of Essential Oil Constituents: An Update
de Cássia da Silveira E, Sá R, Lima TC, da Nóbrega FR, de Brito AEM, de Sousa DP International Journal of Molecular Science, 2017 ABSTRACT: The constituents of essential oils are widely found in foods and aromatic plants giving characteristic odor and flavor. However, pharmacological studies evidence its therapeutic potential for the treatment of several… Read more »
The impact of sesquiterpenes β-caryophyllene oxide and trans-nerolidol on xenobiotic-metabolizing enzymes in mice in vivo
Lněničková K, Svobodová H, Skálová L, Ambrož M, Novák F, Matoušková P Xenobiotica, 2017 ABSTRACT: 1. Sesquiterpenes, constituents of plant essential oil, are popular bioactive compounds due to the positive effect on human health, but their potential toxicity and possible herb-drug interactions are often omitted. In our in vivo study, we followed up the effect of… Read more »
Fragrance allergens linalool and limonene allylic hydroperoxides in skin allergy: mechanisms of action focusing on transcription factor Nrf2
Raffalli C, Clouet E, Kuresepi S, Damiens MH, Lepoittevin JP, Pallardy M, Ferret PJ, Giménez-Arnau E, Kerdine-Römer S Toxicology Science, 2017 ABSTRACT: Allergic contact dermatitis (ACD) is regarded as the most frequent expression of immunotoxicity in humans. Many odorant terpenes commonly used in fragrance compositions are considered as weak skin sensitizers, whereas some of their… Read more »
Hepatotoxicity of monoterpenes and sesquiterpenes
Zárybnický T, Boušová I, Ambrož M, Skálová L Archives of Toxicology, 2017 ABSTRACT: Public interest in natural therapies has increased significantly over past decades. Herbs and herbal products are extensively consumed worldwide and they are generally considered as safe. However, this may not always be true as many cases of herb-induced liver injury are reported… Read more »