Menthol evokes Ca2+ signals and induces oxidative stress independently of the presence of TRPM8 (menthol) receptor in cancer cells.

Nazıroğlu M, Blum W, Jósvay K, Çiğ B, Henzi T, Oláh Z, Vizler C, Schwaller B, Pecze L Redox Biology, 2017 ABSTRACT: Menthol is a naturally occurring monoterpene alcohol possessing remarkable biological properties including antipruritic, analgesic, antiseptic, anti-inflammatory and cooling effects. Here, we examined the menthol-evoked Ca2+ signals in breast and prostate cancer cell lines. The… Read more »

Topical Menthol for Treatment of Chemotherapy-induced Peripheral Neuropathy

Cortellini A, Verna L, Cannita K, Napoleoni L, Parisi A, Ficorella C, Porzio G Indian Journal of Palliative Care, 2017 ABSTRACT: Chemotherapy-induced peripheral neuropathy is a frequent treatment-limiting factor that significantly impairs patients’ everyday life, also because of a lack of valid palliative options. Here, we report a case of a male patient with a history of metastatic… Read more »