Kaur T, Kaul S, Bhardwaj A Phytomedicine, 2018 ABSTRACT: BACKGROUND: Uremia is the condition generally associated with the last stage of chronic kidney disease (CKD) due to highly reduced glomerular filtration rate. Mortality of the patients diagnosed with Uremia generally occurs due to cardiovascular involvement. This occurs due to the transdifferentiation of vascular smooth muscle… Read more »
Lavandula angustifolia Essential Oil and Linalool Counteract Social Aversion Induced by Social Defeat
Caputo L, Reguilon MD, Mińarro J, De feo V, Rodriguez-arias M Molecules, 2018 ABSTRACT: Many vegetable extracts, essential oils, and their main constituents are active on the Central Nervous System (CNS). In fact, they have been used as sedatives, hypnotics, or tranquilizers for their activity in treating CNS disorders. In this research, we studied the… Read more »
Essential oil of lavender in anxiety disorders: Ready for prime time?
Malcolm BJ, Tallian K The Mental Health Clinician, 2018 ABSTRACT: Anxiety disorders are some of the most common psychiatric disorders, with potentially debilitating consequences on individual function. Existing pharmacotherapies for anxiety disorders are limited by delay to therapeutic effect, dependence, tolerance, withdrawal, and abuse potential. Therefore, safe and evidence-based complementary or alternative therapies may be… Read more »
An Overview on Citrus aurantium L.: Its Functions as Food Ingredient and Therapeutic Agent
Suntar I, Khan H, Patel S, Celano R, Rastrelli L Oxidative Medicine and Cellular Longevity, 2018 ABSTRACT: Citrus aurantium L. (Rutaceae), commonly known as bitter orange, possesses multiple therapeutic potentials. These biological credentials include anticancer, antianxiety, antiobesity, antibacterial, antioxidant, pesticidal, and antidiabetic activities. The essential oil of C. aurantium was reported to display marked pharmacological… Read more »
Anti-inflammatory effect of cinnamaldehyde and linalool from the leaf essential oil of Cinnamomum osmophloeum Kanehira in endotoxin-induced mice
Lee SC, Wang SY, Li CC, Liu CT Journal of Food and Drug Analysis, 2018 ABSTRACT: Cinnamomum osmophloeum Kanehira is a Taiwan native plant that belongs to genus Cinnamomum and is also known as pseudocinnamomum or indigenous cinnamon. Its leaf is traditionally used by local people in cooking and as folk therapy. We previously demonstrated… Read more »
Citrus essential oils inhalation by mice: Behavioral testing, GCMS plasma analysis, corticosterone, and melatonin levels evaluation.
Wolffenbüttel AN, Zamboni A, Becker G, Dos Santos MK, Borille BT, de Cássia Mariotti K, Fagundes AC, de Oliveira Salomón JL, Coelho VR, Ruiz LV, de Moura Linck V, Dallegrave E, Cano P, Esquifino AI, Leal MB, Limberger RP Phytotherapy Research, 2017 ABSTRACT: The use of orange essential oils (EOs) as a complementary treatment is very common… Read more »
Linalool-rich essential oils from the Amazon display antidepressant-type effect in rodents
Dos Santos ÉRQ, Maia CSF, Fontes Junior EA, Melo AS, Pinheiro BG, Maia JGS Journal of Ethnopharmacology, 2017 ETHNOPHARMACOLOGICAL RELEVANCE: The essential oils of the leaves of Aniba rosaeodora (pau-rosa), Aniba parviflora (macacaporanga) and Aeollanthus suaveolens (catinga-de-mulata), rich in linalool, are used in the traditional medicine of the Brazilian Amazon for its effects on the central nervous… Read more »
Anti-inflammatory effect of essential oil from Citrus aurantium L. var. amara Engl
Shen CY, Jiang JG, Ou-Yang Q, Zhu W Journal of Agricultural and Food Chemistry, 2017 ABSTRACT: Essential oil has been popularly used as an alternative for the treatment of inflammation. The bioactivities of essential oil from blossoms of Citrus aurantium L. var. amara Engl (CAVAO) showed greater anti-inflammation potential than that of antioxidant, anticancer, and 3T3-L1 proliferation inhibition…. Read more »
(-)-Linalool influence on the cerebral blood flow in healthy male volunteers revealed by three-dimensional pseudo-continuous arterial spin labeling
Ota M, Sato N, Sone D, Ogura J, Kunugi H Indian Journal of Psychiatry, 2017 BACKGROUND: Although aromatherapy is widely used, the pharmacology of the essential oils remains undiscovered. AIM: The present study assessed the effect of (-)-linalool, the main contained material of lavender, on the brain function. MATERIALS AND METHODS: Healthy male volunteers calculated… Read more »
Metabolic Products of Linalool and Modulation of GABAA Receptors
Milanos S, Elsharif SA, Janzen D, Buettner A, Villmann C Frontiers in Chemistry, 2017 ABSTRACT: Terpenoids are major subcomponents in aroma substances which harbor sedative physiological potential. We have demonstrated that various monoterpenoids such as the acyclic linalool enhance GABAergic currents in an allosteric manner in vitro upon overexpression of inhibitory α1β2 GABAA receptors in various expression systems. However, in plants or humans, i.e.,… Read more »