Neffati A, Bouhlel I, Ben Sghaier M, Boubaker J, Limem I, Kilani S, Skandrani I, Bhouri W, Le Dauphin J, Barillier D, Mosrati R, Chekir-Ghedira L, Ghedira K
Environmental Toxicology and Pharmacology, 2009
The SOS-chromotest in Escherichia coli is a widely used bacterial genotoxicity assay to test potential carcinogens. The aim of this work is to evaluate the genotoxic and antigenotoxic activities of essential oils obtained from aerial parts of Pituranthos chloranthus. The tested essential oils were not genotoxic towards both E. coli PQ37 and PQ35 strains. These essential oils reduced significantly Nifuroxazide and H(2)O(2)-induced genotoxicity. Essential oils showed a protective effect against damages induced by radicals, obtained from the photolysis of H(2)O(2), on DNA plasmid through free radical scavenging mechanisms. The scavenging capacity of these essential oils was also estimated by evaluating the inhibition of ABTS(+.) radical.
Neffati A, Bouhlel I, Ben Sghaier M, et al. Antigenotoxic and antioxidant activities of Pituranthos chloranthus essential oils. Environ Toxicol Pharmacol. 2009;27(2):187-194.