Eugenol inhibits oxidative phosphorylation and fatty acid oxidation via downregulation of c-Myc/PGC-1β/ERRα signaling pathway in MCF10A-ras cells

Yan X, Zhang G, Bie F, Lv Y, Ma Y, Ma M, Wang Y, Hao X, Yuan N, Jiang X Scientific Republic, 2017 ABSTRACT: Alteration in cellular energy metabolism plays a critical role in the development and progression of cancer. Targeting metabolic pathways for cancer treatment has been investigated as potential preventive or therapeutic methods…. Read more »

Chemical composition of the essential oils isolated from peel of three citrus species and their mosquitocidal activity against Culex pipiens

Badawy MEI, Taktak NEM, El-Aswad AF Natural Product Research, 2017 ABSTRACT: Three essential oils (EOs) were isolated from the peel of citrus fruits Citrus reticulata L., Citrus reticulata chinase Blanco and Citrus sinensis (L.) Osbeck (Family: Rutaceae) and evaluated against Culex pipiens L.1758 (Family: Culicidae). Chemical composition indicated that the EOs were rich in essential phytochemicals including… Read more »

Perspectives on medicinal properties of natural phenolic monoterpenoids and their hybrids

Rajput JD, Bagul SD, Pete UD, Zade CM, Padhye SB, Bendre RS Molecular Diversity, 2017 ABSTRACT: Carvacrol, thymol and eugenol belong to a class of naturally presenting phenols with a ten-carbon unit, which are present in essential oils of many plants. These versatile molecules are incorporated as useful ingredients in many food products and find applications in… Read more »

Anti-oxidant activity and major chemical component analyses of twenty-six commercially available essential oils

Wang HF, Yih KH, Yang CH, Huang KF Journal of Food and Drug Analysis, 2017 ABSTRACT: This study analyzed 26 commercially available essential oils and their major chemical components to determine their antioxidant activity levels by measuring their total phenolic content (TPC), reducing power (RP), β-carotene bleaching (BCB) activity, trolox equivalent antioxidant capacity (TEAC), and 1,1-diphenyl-2-picrylhydrazyl free… Read more »

Management of behavioral and psychological symptoms of dementia (BPSD) by an aroma-massage with acupressure treatment protocol: a randomized clinical trial

Fung JKK, Tsang HW Journal of Clinical Nursing, 2017 AIMS AND OBJECTIVES: This study evaluates the clinical effectiveness of a multi-component aroma-massage with an acupressure treatment protocol and compared it to cognitive training for the management of BPSD. BACKGROUND: Pharmacological interventions have been unsatisfactory in managing BPSD; thus, complementary and alternative medicine has been extensively… Read more »

Carvacrol-rich oregano oil and thymol-rich thyme red oil inhibit biofilm formation and the virulence of uropathogenic Escherichia coli

Lee JH, Kim YG, Lee J Journal of Applied Microbiology, 2017 AIMS: Urinary tract infections are caused primarily by uropathogenic Escherichia coli (UPEC), and indwelling catheters are usually colonized by UPEC biofilms tolerant to common antibiotics. Hence, UPEC biofilms pose a substantial challenge, and there is an urgent need for effective control strategies. METHODS AND… Read more »

Four terpene synthases contribute to the generation of chemotypes in tea tree (Melaleuca alternifolia)

Padovan A, Keszei A, Hassan Y, Krause ST, Köllner TG, Degenhardt J, Gershenzon J, Külheim C, Foley WJ BMC Plant Biology, 2017 BACKGROUND: Terpene rich leaves are a characteristic of Myrtaceae. There is significant qualitative variation in the terpene profile of plants within a single species, which is observable as “chemotypes”. Understanding the molecular basis… Read more »

Cytotoxic and genotoxic potential of geraniol in peripheral blood mononuclear cells and human hepatoma cell line (HepG2)

Queiroz TB, Santos GF, Ventura SC, Hiruma-Lima CA, Gaivão IOM, Maistro EL Genetics and Molecular Research, 2017 ABSTRACT: Geraniol is an acyclic monoterpene alcohol present in the essential oil of many aromatic plants and is one of the most frequently used molecules by the flavor and fragrance industries. The literature also reports its therapeutic potential, highlighting itself… Read more »

Toxic and repellent activity of selected monoterpenoids (thymol, carvacrol and linalool) against the castor bean tick, Ixodes ricinus (Acari: Ixodidae)

Tabari MA, Youssefi MR, Maggi F, Benelli G Veterinary Parasitology, 2017 ABSTRACT: The castor bean tick, Ixodes ricinus, is a species of medical and veterinary importance. The use of synthetic acaricides for tick control has led to development of resistance, residues in the environment and animal products, and public health concerns. In this regard, plant essential… Read more »

Chemical composition, anti-biofilm activity and potential cytotoxic effect on cancer cells of Rosmarinus officinalis L. essential oil from Tunisia

Jardak M, Elloumi-Mseddi J, Aifa S, Mnif S Lipids in Health and Disease, 2017 BACKGROUND: Rosmarinus officinalis L. from Tunisia, popularly known as rosemary, is of a considerable importance for its medicinal uses and aromatic value. The aim of this study was to examine the chemical composition of Rosmarinus officinalis essential oil (ROEO) and to evaluate its… Read more »