Fragrance compounds and essential oils with sedative effects upon inhalation

Buchbauer G, Jirovetz L, Jager W, Plank C, Dietrich H
Journal of Pharmaceutical Sciences, 1993


Fragrance compounds and essential oils with sedative effects influence the motility of mice ininhalation studies under standardized conditions. A significant drop in the motility of mice was registered following exposure to these fragrances. The same results were achieved when the mice were artificially induced into overagitation by intraperitoneal application of caffeine and subsequently subjected to inhalation of fragrance compounds and essential oils. These results proved thesedative effects of these fragrants via inhalative exposure in low concentrations. Blood samples were taken from the mice after a 1-h inhalation period. Chromatographic and spectroscopic methods were used to detect and characterize the actual effective compounds after solid-phase extraction. Serum concentrations of 42 different substances, including fragrance compounds, were found in low ranges (ng/mL serum). The results contribute to the correct interpretation of the term aromatherapy (i.e., a stimulating or sedative effect on the behaviour of individuals only uponinhalation of fragrance compounds).


Buchbauer G, Jirovetz L, Jager W, et al. Fragrance compounds and essential oils with sedative effects upon inhalation. J Pharm Sci. 1993;82(6):660-664.

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