Na HJ, Koo HN, Lee GG, Yoo SJ, Park JH, Lyu YS, Kim HM
Clinica Chimica Acta, 2001
ABSTRACT:
BACKGROUND:
Brain astrocytes play a pivotal role in neuronal activities.
METHODS:
An investigation was undertaken to determine whether juniper oil inhibits heat shock-induced apoptosis of astrocytes.
RESULTS:
Juniper oil inhibited the heat shock-induced apoptosis in human astrocyte CCF-STTG1 cells. Pretreatment of the cells with juniper oil inhibited the heat shock-induced DNA fragmentation and condensation of nuclear chromatin. Juniper oil alone did not affect the apoptosis. Juniper oil inhibited the heat shock-induced caspase-3 activation and poly-ADP-ribose polymerase (PARP) fragmentation in the human astrocytes.
CONCLUSIONS:
Juniper oil may inhibit the apoptosis of astrocytes by preventing the caspase-3 activation.
CITATION:
Na HJ, Koo HN, Lee GG, et al. Juniper oil inhibits the heat shock-induced apoptosis via preventing the caspase-3 activation in human astrocytes CCF-STTG1 cells. Clin Chim Acta. 2001;314(1-2):215-220.
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