Expression of P53, BAX, and BCL-2 in human malignant melanoma and squamous cell carcinoma cells after tea tree oil treatment in vitro

Ramadan MA, Shawkey AE, Rabeh MA, Abdellatif AO Cytotechnology, 2019 ABSTRACT: Tea tree oil (TTO) is an essential oil obtained by steam distillation from the leaves of Melaleuca alternifolia (Myrtaceae). This oil has traditionally been used for the treatment of various skin infections. The present study aimed to investigate the cytotoxic effects of TTO against… Read more »

Effectiveness of topical administration of Anethum graveolens essential oil on MRSA-infected wounds

Manzuoerh R, Farahpour MR, Oryan A, Sonboli A Biomedicine and Pharmacotherapy, 2019 ABSTRACT: Medicinal plants are conventionally used for wound healing, but their action mechanisms are still unknown. The present study evaluated the effect of topical administration of ointment containing dill (Anethum graveolens) essential oil (DEO) in the management of apoptosis and cell proliferation during… Read more »

Induction of apoptosis by essential oil from P. missionis in skin epidermoid cancer cells

Pavithra PS, Mehta A, Verma RS Phytomedicine, 2018 ABSTRACT: BACKGROUND: The genus Pamburus (Rutaceae) comprises the only species, Pamburus missionis (Wight) Swingle. Pamburus missionis is traditionally used in the treatment of swellings, chronic rheumatism, paralysis and puerperal diseases. PURPOSE: The present study investigates the cancer chemotherapeutic potential of essential oil (EO) from P. missionis. METHODS:… Read more »

Safranal protects against beta-amyloid peptide-induced cell toxicity in PC12 cells via MAPK and PI3 K pathways

Rafieipour F, Hadipour E, Emami SA, Asili J, Tayarani-najaran Z Metabolic Brain Disease, 2018 ABSTRACT: Alzheimer’s disease is a type of cerebrovascular problem with progressive mental disabilities for the patient. This study aimed to investigate the protective effect of safranal on toxicity and oxidative damage induced by beta-amyloid (Aβ) and hydrogen peroxide (H2O2) in PC12… Read more »

Anti-proliferative activity of Origanum vulgare inhibited lipogenesis and induced mitochondrial mediated apoptosis in human stomach cancer cell lines

Balusamy SR, Perumalsamy H, Huq MA, Balasubramanian B Biomedicine and Pharmacotherapy, 2018 ABSTRACT: Origanum vulgare commonly known as oregano belongs to mint family (Laminaceae), and native to temperate western and mediterranean region. In our present study, we have identified the bio-active principles of oregano essential oil (EO) and evaluated its apoptotic effects against human stomach… Read more »

Synergistic interaction of β-caryophyllene with aromadendrene oxide 2 and phytol induces apoptosis on skin epidermoid cancer cells

Pavithra PS, Mehta A, Verma RS Phytomedicine, 2018 ABSTRACT: BACKGROUND: Pamburus missionis (Wight) Swingle (Rutaceae) is traditionally used in the treatment of swellings, chronic rheumatism, paralysis and puerperal diseases. In a previous study the authors demonstrated apoptotic activity of Pamburus missionis essential oil (EO) on A431 and HaCaT cells. The major components of EO were… Read more »

Essential Oil Derived From Eupatorium adenophorum Spreng. Mediates Anticancer Effect by Inhibiting STAT3 and AKT Activation to Induce Apoptosis in Hepatocellular Carcinoma

Chen H, Zhou B, Yang J, Ma X, Deng S, Huang Y, Wen Y, Yuan J, Yang X Frontiers in Pharmacology, 2018 ABSTRACT: Eupatorium adenophorum Spreng. (EA) is a well-known noxious invasive species. Gas chromatography-mass spectrometry (GC-MS) analysis revealed that the essential oil derived from EA (EAEO) is mainly composed of sesquiterpenes. However, the pharmacological… Read more »

Thymoquinone protects rat liver after partial hepatectomy under ischemia/reperfusion through oxidative stress and endoplasmic reticulum stress prevention

Bouhlel A, Bejaoui M, Ben Mosbah I, Hadj Abdallah N, Ribault C, Viel R, Hentati H, Corlu A, Ben Abdennebi H Clinical and Experimental Pharmacology and Physiology, 2018 ABSTRACT: Ischemia reperfusion (I/R) is associated with liver injury and impaired regeneration during partial hepatectomy (PH). The aim of this study was to investigate the effect of… Read more »

Lemongrass essential oil and citral inhibit Src/Stat3 activity and suppress the proliferation/survival of small-cell lung cancer cells, alone or in combination with chemotherapeutic agents

Maruoka T, Kitanaka A, Kubota Y, Yamaoka G, Kameda T, Imataki O, Dobashi H, Bandoh S, Kadowaki N, Tanaka T International Journal of Oncology, 2018 ABSTRACT: Small-cell lung cancer (SCLC) is intractable due to its high propensity for relapse. Novel agents are thus needed for SCLC treatment. Lemongrass essential oil (LG-EO) and its major constituent,… Read more »

Involvement of Bax and Bcl-2 in Induction of Apoptosis by Essential Oils of Three Lebanese Salvia Species in Human Prostate Cancer Cells

Russo A, Cardile V, Graziano ACE, Avola R, Bruno M, Rigano D International Journal of Molecular Sciences, 2018 ABSTRACT: Prostate cancer is one of the most common forms of cancer in men, and research to find more effective and less toxic drugs has become necessary. In the frame of our ongoing program on traditionally used… Read more »