Studies on the metabolism of d-limonene (p-mentha-1,8-diene). I. The absorption, distribution and excretion of d-limonene in rats.

Igimi H, Nishimura M, Kodama R, Ide H
Xenobiotica; the fate of foreign compounds in biological systems, 1974


ABSTRACT:

1. The absorption, distribution and excretion of d-limonene were investigated in rats using the 14C-labelled compound.

2. The highest concentration of radioactivity in blood was obtained 2 h after oral administration of [14C]d-limonene and most occurred in the serum fraction. Radioactivity in the tissues reached maximum 1 or 2 h after administration. Radioactivity in liver, kidney and blood was higher than in other tissues, but was negligible 48 h after administration. An autoradiographic study confirmed these findings of tissue distribution.

3. About 60% of administered radioactivity was recovered from urine, 5% from faeces and 2% from expired CO2 within 48 h. In bile duct cannulated rats, about 25% of the dose was excreted in bile within 24 h.

CITATION:

Igimi H, Nishimura M, Kodama R et al. Studies on the metabolism of d-limonene (p-mentha-1,8-diene). I. The absorption, distribution and excretion of d-limonene in rats. Xenobiotica. 1974;4(2):77-84.


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