Negative inotropism of terpenes on guinea pig left atrium: structure-activity relationships

Vasconcelos CML, Oliveira ISN, Santos JNA, Souza AA, Menezes-Filho JER, Silva Neto JA, Lima TC, de Sousa DP Natural Product Research, 2017 ABSTRACT: The aim of this work was to evaluate the pharmacological effect of seven structurally related terpenes on the contractility of cardiac muscle. The effect of terpenes was studied on isolated electrically driven guinea pig left atrium. From concentration-response curves… Read more »