Negative inotropism of terpenes on guinea pig left atrium: structure-activity relationships

Vasconcelos CML, Oliveira ISN, Santos JNA, Souza AA, Menezes-Filho JER, Silva Neto JA, Lima TC, de Sousa DP
Natural Product Research, 2017


ABSTRACT:

The aim of this work was to evaluate the pharmacological effect of seven structurally related terpenes on the contractility of cardiac muscle. The effect of terpenes was studied on isolated electrically driven guinea pig left atrium. From concentration-response curves for inotropic effect were determined the EC50 and relative potency of such terpenes. Our results revealed that all terpenes, except phytol, showed ability to reduce the contractile response of guinea pig left atrium. Further, relative potency was directly related to the number of isoprene units and to the lipophilicity of the compounds. For example, sesquiterpenes farnesol and nerolidol showed higher relative potency when compared with the monoterpenes citronellol, geraniol and nerol. We can conclude that most of the evaluated terpenes showed a promising negative inotropism on the atrial muscle. Future studies are necessary to investigate their action mechanism.

CITATION:

Vasconcelos CML, Oliveira ISN, Santos JNA et al. Negative inotropism of terpenes on guinea pig left atrium: structure-activity relationships. Nat Prod Res. 2017 Jun 23:1-4. doi: 10.1080/14786419.2017.1344658.


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