Variation on composition and bioactivity of essential oils of four common Curcuma herbs

Zhang L, Yang Z, Chen D, Huang Z, Li Y, Lan X, Su P, Pan W, Zhou W, Zheng X, Du Z
Chemistry & Biodiversity, 2017


Chemical compositions, antioxidative, antimicrobial, anti-inflammatory and cytotoxic activities of essential oils extracted from four common Curcuma species (Curcuma longa, Curcuma phaeocaulis, Curcuma wenyujin and Curcuma kwangsiensis) rhizomes in China are comparatively studied. In total, 47, 49, 35 and 30 compounds are identified in C. longa, C. phaeocaulis, C. wenyujin and C. kwangsiensis essential oils by GC-MS, and their richest compounds are ar-turmerone (21.67%), elemenone (19.41%), curdione (40.23%) and (36.47%), respectively. Moreover, C. kwangsiensis essential oils display the strongest DPPH (2,2-diphenyl-1-picrylhydrazyl) radical-scavenging activity (IC50 , 3.47 μg/ml), much higher than ascorbic acid (6.50 μg/ml). C. phaeocaulis oils show the best antibacterial activities against E. coli (MIC, 235.54 μg/ml), P. aeruginosa (391.31 μg/ml) and S. aureus (378.36 μg/ml), while C. wenyujin and C. kwangsiensis oils show optimum activities against C. albicans (208.61 μg/ml) and S. cerevisiae (193.27 μg/ml), respectively. C. phaeocaulis (IC50 , 4.63 μg/ml) and C. longa essential oils (73.05 μg/ml) have the best cytotoxicity against LNCaP and HepG2, respectively. C. kwangsiensis oils also exhibit the strongest anti-inflammatory activities by remarkably down-regulating expression of COX-2 and TNF-α. Therefore, due to their different chemical compositions and bioactivities, traditional Chinese Curcuma herbs should be differentially served as natural additives for food, pharmaceutical and cosmetic. This article is protected by copyright. All rights reserved.


Zhang L, Yang Z, Chen D. Variation on composition and bioactivity of essential oils of four common Curcuma herbs. Chem Biodivers. 2017 Aug 10. doi: 10.1002/cbdv.201700280.

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