Lignans from Santalum album and their cytotoxic activities

Matsuo Y, Mimaki Y
Chemical and Pharmaceutical Bulletin, 2010


A new neolignan, (7R,8R)-5-O-demethylbilagrewin (1), together with four known lignans (2—5), were isolated from the heartwood of Santalum album (Santalaceae). The structure of 1 was determined by analysis of extensive spectroscopic data. The isolated compounds and derivatives were evaluated for their cytotoxic activities against HL-60 human promyelocytic leukemia cells and A549 human lung adenocarcinoma cells. Compounds 1 and 2 exhibited cytotoxicity against HL-60 cells with IC50 values of 1.5±0.02 and 4.3±0.13 μM, and against A549 cells with IC50 values of 13.6±0.32 and 19.9±1.27 μM, respectively. The aldehyde group of 1 and 2 was revealed to be a structural requirement for the appearance of cytotoxicity in this type of lignans. These tumor cell deaths were shown to be mediated through induction of apoptosis.


Matsuo Y, Mimaki Y. Lignans from Santalum album and their cytotoxic activities. Chem Pharm Bull. 2010;58(4):587-590.

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