Matsuo Y, Mimaki Y
Chemical and Pharmaceutical Bulletin, 2010
ABSTRACT:
A new neolignan, (7R,8R)-5-O-demethylbilagrewin (1), together with four known lignans (2—5), were isolated from the heartwood of Santalum album (Santalaceae). The structure of 1 was determined by analysis of extensive spectroscopic data. The isolated compounds and derivatives were evaluated for their cytotoxic activities against HL-60 human promyelocytic leukemia cells and A549 human lung adenocarcinoma cells. Compounds 1 and 2 exhibited cytotoxicity against HL-60 cells with IC50 values of 1.5±0.02 and 4.3±0.13 μM, and against A549 cells with IC50 values of 13.6±0.32 and 19.9±1.27 μM, respectively. The aldehyde group of 1 and 2 was revealed to be a structural requirement for the appearance of cytotoxicity in this type of lignans. These tumor cell deaths were shown to be mediated through induction of apoptosis.
CITATION:
Matsuo Y, Mimaki Y. Lignans from Santalum album and their cytotoxic activities. Chem Pharm Bull. 2010;58(4):587-590.
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