Construction of cell factories for high production of nerolidol in Saccharomyces cerevisiae (Chinese)

Zhang LL, Ma XL, Wang D, Yu P, Huang LQ, Zhang XL, Dai ZB Zhongguo Zhong Yao Za Zhi, 2017 ABSTRACT: Nerolidol is an important constituent of terpenoid essential oil and has excellent anti-tumor, anti-bacterial, and anti-oxidative properties. For realizing heterogenous production of nerolidol, our research firstly integrated the codon-optimized Actinidia sinensis nerolidol synthase gene (NES) into the… Read more »

The impact of sesquiterpenes β-caryophyllene oxide and trans-nerolidol on xenobiotic-metabolizing enzymes in mice in vivo

Lněničková K, Svobodová H, Skálová L, Ambrož M, Novák F, Matoušková P Xenobiotica, 2017 ABSTRACT: 1. Sesquiterpenes, constituents of plant essential oil, are popular bioactive compounds due to the positive effect on human health, but their potential toxicity and possible herb-drug interactions are often omitted. In our in vivo study, we followed up the effect of… Read more »

Antiparasitic activity of nerolidol in a mouse model of schistosomiasis

Silva MP, de Oliveira RN, Mengarda AC, Roquini DB, Alegretti SM, Salvadori MC, Teixeira FS, de Sousa DP, Pinto PLS, de Moraes J International Journal of Antimicrobial Agents, 2017 ABSTRACT: Schistosomiasis is a major public health problem worldwide, especially in poor communities. Since praziquantel is currently the only drug available to treat schistosomiasis, there is an urgent need to identify new antischistosomal drugs. Nerolidol… Read more »

Negative inotropism of terpenes on guinea pig left atrium: structure-activity relationships

Vasconcelos CML, Oliveira ISN, Santos JNA, Souza AA, Menezes-Filho JER, Silva Neto JA, Lima TC, de Sousa DP Natural Product Research, 2017 ABSTRACT: The aim of this work was to evaluate the pharmacological effect of seven structurally related terpenes on the contractility of cardiac muscle. The effect of terpenes was studied on isolated electrically driven guinea pig left atrium. From concentration-response curves… Read more »