Skalicka-Woźniak K, Walasek M, Aljarba TM, Stapleton P, Gibbons S, Xiao J, Łuszczki JJ Food and Chemical Toxicology, 2018 ABSTRACT: The high-performance counter-current chromatography was used for the efficient purification of single constituents from Thymus vulgaris essential oil. Mixtures of n-heptane, ethyl acetate, methanol, and water (5:2:5:2 and 4:1:4:1 v/v), allowed purification of eugenol, 1-octen-3-… Read more »
Nanoemulsions containing Cymbopogon flexuosus essential oil: Development, characterization, stability study and evaluation of antimicrobial and antibiofilm activities
da Silva Gündel S, de Souza ME, Quatrin PM, Klein B, Wagner R, Gündel A, Vaucher RA, Santos RCV, Ourique AF Microbial Pathogenesis, 2018 ABSTRACT: The increase of microbial resistance generates the search for new substances with antimicrobial potential. The essential oil of Cymbopogon flexuosus (Lemongrass) stands out in the literature for its antimicrobial, insecticide… Read more »
Anti-Leishmania and cytotoxic activities of perillaldehyde epoxide synthetic positional isomers
Keesen TSL, da Silva LV, da Câmara Rocha J, Andrade LN, Lima TC, de Sousa DP Natural Product Research, 2018 ABSTRACT: Leishmaniasis belongs to a complex of zoonotic disease caused by protozoa of the genus Leishmania and is considered a major public health problem. Several essential oil chemical components have inhibitory effect against protozoa, including… Read more »
Analgesic-Like Activity of Essential Oil Constituents: An Update
de Cássia da Silveira E, Sá R, Lima TC, da Nóbrega FR, de Brito AEM, de Sousa DP International Journal of Molecular Science, 2017 ABSTRACT: The constituents of essential oils are widely found in foods and aromatic plants giving characteristic odor and flavor. However, pharmacological studies evidence its therapeutic potential for the treatment of several… Read more »
Lactoferrin, chitosan and Melaleuca alternifolia-natural products that show promise in candidiasis treatment
Felipe LO, Júnior WFDS, Araújo KC, Fabrino DL Brazilian Journal of Microbiology, 2017 ABSTRACT: The evolution of microorganisms resistant to many medicines has become a major challenge for the scientific community around the world. Motivated by the gravity of such a situation, the World Health Organization released a report in 2014 with the aim of… Read more »
Cardiovascular Activity of the Chemical Constituents of Essential Oils
de Andrade TU, Brasil GA, Endringer DC, da Nóbrega FR, de Sousa DP Molecules, 2017 ABSTRACT: Cardiovascular diseases are a leading cause of death in developed and developing countries and decrease the quality of life, which has enormous social and economic consequences for the population. Recent studies on essential oils have attracted attention and encouraged continued research… Read more »
(+)-Dehydrofukinone modulates membrane potential and delays seizure onset by GABAa receptor-mediated mechanism in mice
Garlet QI, da Costa Pires L, Milanesi LH, Marafiga JR, Baldisserotto B, de Mello CF, Heinzmann BM Toxicology and Applied Pharmacology, 2017 ABSTRACT: (+)-Dehydrofukinone (DHF), isolated from Nectandra grandiflora (Lauraceae) essential oil, induces sedation and anesthesia by modulation of GABAa receptors. However, no study has addressed whether DHF modulates other cellular events involved in the control of cellular excitability, such as seizure… Read more »
Potential role of natural compounds as anti-angiogenic agents in cancer
Shanmugam MK, Warrier S, Kumar AP, Sethi G, Arfuso F Current Vascular Pharmacology, 2017 ABSTRACT: BACKGROUND: Neovascularization, also known as angiogenesis, is the process of capillary sprouting from pre-existing blood vessels. This physiological process is a hallmark event in normal embryonic development as blood vessels generally supply both oxygen and nutrients to the cells of the body. Any disruption… Read more »