Thymus vulgaris L. and thymol assist murine macrophages (RAW 264.7) in the control of in vitro infections by Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans

de Oliveira JR, Figueira LW, Sper FL, Meccatti VM, Camargo SEA, de Oliveira LD Immunologic Research, 2017 ABSTRACT: Microorganisms are capable to combat defense cells by means of strategies that contribute to their stabilization and proliferation in invaded tissues. Frequently antimicrobial-resistant strains appear; therefore, alternative methods to control them must be investigated, for example, the use of plant products. The… Read more »

Development of antimicrobial nanoemulsion-based delivery systems against selected pathogenic bacteria using a thymol rich Thymus daenensis essential oil

Ghaderi L, Moghimi R, Aliahmadi A, McClements DJ, Rafati H Journal of Applied Microbiology, 2017 ABSTRACT: AIMS: Thymol rich medicinal plants have been used in traditional medicine to relieve infectious diseases. However, the application of essential oils as medicine is limited by its low water-solubility and high vapor pressure. The objective of this study was to produce stable nanoemulsions of Thymus daenensis oil in… Read more »

Essential Oil Characterization of Thymus vulgaris from Various Geographical Locations

Satyal P, Murray BL , McFeeters RL, Setzer WN Foods, 2016 ABSTRACT: Thyme (Thymus vulgaris L.) is a commonly used flavoring agent and medicinal herb. Several chemotypes of thyme, based on essential oil compositions, have been established, including (1) linalool; (2) borneol; (3) geraniol; (4) sabinene hydrate; (5) thymol; (6) carvacrol, as well as a… Read more »

Thymol reduces oxidative stress, aortic intimal thickening, and inflammation-related gene expression in hyperlipidemic rabbits

Yua YM, Chaob TY, Changb WC, Changb MJ, Leea MF Journal of Food and Drug Analysis, 2016 ABSTRACT: Atherosclerosis plays a key role in the development of cardiovascular diseases, and is often associated with oxidative stress and local inflammation. Thymol, a major polyphenolic compound in thyme, exhibits antioxidant and anti-inflammatory properties. In this study, we… Read more »

The protective effects of carvacrol and thymol against paracetamol-induced toxicity on human hepatocellular carcinoma cell lines (HepG2)

Palabiyik SS, Karakus E, Halici Z, Cadirci E, Bayir Y, Ayaz G, Cinar I Human & experimental toxicology, 2016 ABSTRACT: Acetaminophen (APAP) overdose could induce liver damage and lead to acute liver failure. The treatment of APAP overdoses could be improved by new therapeutic strategies. Thymus spp., which has many beneficial effects and has been… Read more »

Chitin-Induced Airway Epithelial Cell Innate Immune Responses Are Inhibited by Carvacrol/Thymol

Khosravi AR, Erle DJ PloS one, 2016 ABSTRACT: Chitin is produced in large amounts by fungi, insects, and other organisms and has been implicated in the pathogenesis of asthma. Airway epithelial cells are in direct contact with environmental particles and serve as the first line of defense against inhaled allergens and pathogens. The potential contributions… Read more »

Thymol, a constituent of thyme essential oil, is a positive allosteric modulator of human GABA(A) receptors and a homo-oligomeric GABA receptor from Drosophila melanogaster

Priestley CM, Williamson EM, Wafford KA, Sattelle DB British journal of pharmacology, 2003 ABSTRACT: The GABA-modulating and GABA-mimetic activities of the monoterpenoid thymol were explored on human GABAA and Drosophila melanogaster homomeric RDLac GABA receptors expressed in Xenopus laevis oocytes, voltage-clamped at -60 mV. The site of action of thymol was also investigated. Thymol, 1-100… Read more »

Plant essential oils for pest and disease management

Murray B Isman Crop Protection, 2000 ABSTRACT: Certain essential plant oils, widely used as fragrances and flavors in the perfume and food industries, have long been reputed to repel insects. Recent investigations in several countries confirm that some plant essential oils not only repel insects, but have contact and fumigant insecticidal actions against specific pests,… Read more »

Antibacterial and antifungal activities of thymol: A brief review of the literature

Marchesea A, Orhanb IE, Dagliac M, Barbieria R, Lorenzoc AD, Nabavid SF, Gortzie O, Izadif M, Nabavid SM Food Chemistry, 2016 ABSTRACT: Thymol (2-isopropyl-5-methylphenol) is the main monoterpene phenol occurring in essential oils isolated from plants belonging to the Lamiaceae family (Thymus, Ocimum,Origanum, and Monarda genera), and other plants such as those belonging to the… Read more »

In-vitro effects of Thymus munbyanus essential oil and thymol on human sperm motility and function

Chikhoune A, Stouvenel L, Iguer-Ouada M, Hazzit M, Schmitt A, Lorès P, Wolf JP, Aissat K, Auger J, Vaiman D, Touré A Reproductive biomedicine online, 2015 ABSTRACT: Traditional medicine has been used worldwide for centuries to cure or prevent disease and for male or female contraception. Only a few studies have directly investigated the effects… Read more »